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The same centrifugation conditions were used as described in Section 3

These alterations result in decreased melanogenesis, mediated by MITF and tyrosinase, and hinder the transfer of melanosomes to precortical matrix keratinocytes

2008 Apr;118(4):1468-78

Pharmacological interventions such as orlistat or GLP-1 receptor agonists may be considered for patients with BMI 30 kg/m who have not achieved adequate weight loss through lifestyle measures alone